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Description

Yoshino, J., Baur, J

[Abstract]2022 Feb 7;18(4):1737-1754

The reaction works like this: NADPH + GSSG NADP+ + 2GSH

More than 80-90% of total ROS are reportedly generated by mitochondrial electron chain Complexes I and III, and NADPH after oxidation by NOXs (NADPH oxidases) is another important source of O 2 - and H 2 O 2 producing-proteins in signal transduction[75, 76]